192 KB34 KB192920262005Zaletel, Marjanštevilka:2letnik:74str. 83-88ISSN:1318-0347COBISSID_HOST:19200729URN:URN:NBN:SI:doc-ZDSKMM91slSlovensko zdravniško društvoZdravniški vestnikBlood Flow VelocityCerebral ArteriesContrast SensitivityEvocirani potenciali vidniEvoked Potentials, VisualKontrastna občutljivostKrvni pretok, hitrostMigraineMigrenaMožganske arterijeUltrasonografija dopplerska, transkranialnaUltrasonography, Doppler, TranscranialAnaliza živčno-žilne sklopitve pri bolnikih z migreno| Analysis of neurovascular coupling in migraneours|Background. According to recent data it is not clear whether neurovascular coupling is disturbed in migraneours during headache free period. The aim of our study was to establish whether the relationship between visually evoked cerebral blood flow responses (VEFR) and visual evoked potentials (VEP) is changed in migraneours during headache free period. Methods. The records were made from 30 healthy volunteers and 30 migraine patients. The mean arterial velocity in the left middle cerebral artery and the mean arterial velocity in rightposterior cerebral artery were monitored by using transcranial Doppler ultrasound. The VEP were recorded from occipital leads. Neuronal activity was changed by changing visual contrast. Results. We found that significant and moderate relationship between the vEP and the VEFR (r = 0. 66; p < 0. 01) in healthy subjects and in migraneours as well (r = 0.63; p < 0.01). The difference between the regression slopes of the healthy subjects (b = 0.55) and the patients with migraine (b = 0.88) was significant (p = 0. 04). Conclusions. We concluded that neurovascular coupling in migraneours during headache free period is more active than in healthy subjectsIzhodišča. Iz dosedanjih študij ni znano, ali je živčno žilna sklopitev pri bolnikih z migreno v času brez migrenskih napadov spremenjena. Zato smo v študiji skušali ugotoviti, ali se povezava med vidnimi evociranimi možganskimiodgovori krvnega pretoka (VEOP) in vidnimi evociranimi potenciali (VEP) razlikuje od povezave pri zdravih preiskovancih. Metode. v raziskavo smovključili 30 zdravih preiskovancev in 30 bolnikov z migreno. Srednjo arterijsko hitrost v levi srednji možganski arteriji in desni zadnji možganskiarteriji smo merili z ultrazvočno transkranialno doplersko preiskavo.VEP smo izmerili iz zatilnih odvodov. Električno nevronsko aktivnostsmo spreminjali s spreminjanjem vidnega kontrasta. Rezultati. vEP in VEOP so bili tako pri zdravih preiskovancih (r = 0, 66; p < 0, 01) kot pri bolnih z migreno (r = 0, 63; p < 0, 01) zmerno statistično pomembno povezani. Naklon regresijske premice je bil pri bolnikih z migreno b = 0, 88 (SE = 0, 07) in pri zdravih preiskovacih b = 0,55 (SE = 0, 08). Razlika med naklonoma je bila statistično pomembna (p = 0, 04). Zaključki. Na temelju rezultatov smozaključili, da je živčnožilna sklopitev pri bolnikih z migreno v času brez napadov aktivnejša kot pri zdravih preiskovancihTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo