{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ZMDUQOGJ/500ce93e-a5ba-4368-9a6e-367013e6fd25/HTML","dcterms:extent":"29 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ZMDUQOGJ/4deb940d-519b-4495-ab2f-2e461ed7d318/PDF","dcterms:extent":"179 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ZMDUQOGJ/1ae48955-aaa9-40d2-9241-d77d47655a5d/TEXT","dcterms:extent":"29 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-ZMDUQOGJ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2007","dc:creator":["Križančić Bombek, Lidija","Vlaisavljević, Veljko"],"dc:format":[{"@xml:lang":"sl","#text":"6 strani"},{"@xml:lang":"sl","#text":"letnik:76"},{"@xml:lang":"sl","#text":"številka:9"},{"@xml:lang":"sl","#text":"str. 545-550"}],"dc:identifier":["ISSN:1318-0347","COBISSID:2757951","URN:URN:NBN:SI:doc-ZMDUQOGJ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"Blastocista"},{"@xml:lang":"en","#text":"Blastocyst"},{"@xml:lang":"sl","#text":"Celično jedro"},{"@xml:lang":"en","#text":"Cell Nucleus"},{"@xml:lang":"en","#text":"Embryo"},{"@xml:lang":"en","#text":"fertilization"},{"@xml:lang":"en","#text":"Infertility"},{"@xml:lang":"en","#text":"methods"},{"@xml:lang":"sl","#text":"Metode"},{"@xml:lang":"sl","#text":"morfologija"},{"@xml:lang":"sl","#text":"Neplodnost"},{"@xml:lang":"sl","#text":"oploditev"},{"@xml:lang":"sl","#text":"razvoj"},{"@xml:lang":"en","#text":"Reproductive Techniques, Assisted"},{"@xml:lang":"sl","#text":"Reproduktivne tehnike, asistirane"},{"@xml:lang":"sl","#text":"selekcija"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"en","#text":"ultrastructure"},{"@xml:lang":"sl","#text":"Ultrastruktura"},{"@xml:lang":"sl","#text":"umetna oploditev"},{"@xml:lang":"sl","#text":"Zarodek"},{"@xml:lang":"sl","#text":"Zdravljenje"},{"@xml:lang":"sl","#text":"Zigota"},{"@xml:lang":"en","#text":"Zygote"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Vpliv morfologije pronukleusov v zigoti na razvoj človeškega zarodka v pogojih in vitro| The influence of zygote pronuclear morphology on in vitro human embryo development|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. The selection of embryos with largest implantation potential is an important part in assisted reproduction. Besides the embryo or blastocyst morphology, selection criteria such as position and orientation of pronuclei (PN) in relation to polar body positioning and the number, size and distribution of nucleolar precursor bodies (NPB) have been proposed. In our study, a correlation between PN and NBP morphology with the development of early embryos (day 2 of cultivation) and blastocysts (day 5) was investigated. Methods. 653 zygotes from 113 IVF (in vitro fertilization) and ICSI (intracytoplasmic sperm injection) patients, younger than 40 years, were assessed 18-20 hours post-insemination. Optimal zygotes (Z1) had thouching centrally located PN with equall numbers of alligned NPB. Other zygote types differred from Z1 in having scattered NPB in both PN (Z2) or alligned NPB in one PN (Z3) or in PN beeing distant from one another (Z4). For each zygote type a percentage of normal early embryos and blastocysts was calculated. Results. Among 653 assessed zygotes 21.8 % were Z1; 29.1 % Z2, 34.6 % Z3 and 14.5 % Z4. The percentage of normal early embryos decreased from Z1 to Z4 zygote type (70.4 % vs. 55.3 % vs. 59.7 % vs.45.3 %č p < 0.05) as well as the percentage of developed blastocysts (63.4 % vs. 55.3 % vs. 58.8 % vs. 43.2 %). However, the percentages of optimal blastocysts in the four groups did not differ (11.3 % vs. 11.1 % vs. 8.4 % vs. 6.3 %). Conclusions. Best grade zygotes result in batter early embryo and blastocyst development suggesting that zygote morphology can be used in combination with embryo and/or blastocyst evaluation as a method for embryo selection prior to embryo transfer"},{"@xml:lang":"sl","#text":"Izhodišča. Pomemben del postopka zunajtelesne oploditve je izbira najbolj kakovostnih zarodkov za prenos v maternico. V zadnjih letih se kot selekcijsko merilo poleg morfologije zarodkov in blastocist navaja ocenjevanje lege in orientacije pronukleusov (PN) glede na lego polarnih teles ter velikost, število in razporeditev nukleolarnih prekurzorskih telesc (NPT). V študiji smo proučevali vpliv izgleda in lege pronukleusov ter razporeditve NPT na razvoj manjceličnih zarodkov in blastocist. Metode. Pri 113 bolnicah, mlajših od 40 let, zdravljenih s postopki oploditve z biomedicinsko pomočjo (z dodajanjem semenčic k jajčni celici - IVF angl. in vitro fertilization ali z neposrednim vnosom semenčice v jajčno celico angl. intracytoplasmic sperm injection - ICSI), smo 18-20 ur po inseminaciji ocenili 653 zigot. Optimalne zigote Z1 so imele centralno ležeče, dotikajoče PN in enakoštevilna, poravnana NPT. Ostali tipi so od Z1 odstopali po naslednjih značilnostih: Z2 - neporavnana NPT v obeh PN; Z3 - neporavnana NPT v enem PN; Z4 - nedotikajoča se PN. Za vsak tip zigote smo določili delež morfološko normalnih manjceličnih zarodkov in optimalnih blastocist, ki so se razvile iz njih. Rezultati. Med zigotami je bilo 21,8 % Z1, 29,1 % Z2, 34,6 % Z3 in 14,5 % Z4 zigot. Delež morfološko normalnih manjceličnih zarodkov je upadal od tipa Z1 proti tipu Z4 (70,4 % oz. 55,3 % oz. 59,7 % oz. 45,3 %; p<0,05), prav tako tudi delež razvitih blastocist (63,4% oz. 55,3 % oz. 58,8 % oz. 43.2 %). Deleži optimalnih blastocist pa se med skupinami statistično niso razlikovali (11,3 % oz. 11,1 % oz. 8,4 oz. 6,3 %). Zaključki. Boljši razvoj manjceličnih zarodkov in blastocist iz zigot z dobro morfološko oceno PN kaže na to, da je morfologija pronukleusov pomemben napovedni dejavnih za nadaljnji razvoj zigote in skupaj z morfologijo zarodkov in blastocist omogoča izbor najprimernejših zarodkov za prenos v maternico"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-ZMDUQOGJ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-ZMDUQOGJ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-ZMDUQOGJ/4deb940d-519b-4495-ab2f-2e461ed7d318/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-ZMDUQOGJ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-ZMDUQOGJ"}}}}