Paralitični ileus kot zaplet zdravljenja z vinkristinom in itrakonazolom
Paralytic ileus as a side effect of vincristine and itraconazole treatment

slovenian

2003

volume 72, issue 9

Adverse Effects   Chemically Induced   Drug Therapy   Intestinal Pseudo-Obstruction   Itraconazole   Itrakonazol   Leukemia, Lymphocytic, Acute   Middle Age   therapy   Vincristine

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background. Vincristin is an important and frequently used chemoterapeutic drug in the treatment of malignant lymphoproliferative disease. Among its sideeffects are well known bone marrow supression and polyneuropathia. But common physicians are not familiar with vincristine bowel peristaltics inhibitory effect. Patient and methods. This study presents 64 years old patient with acute lymphoblastic leukemia (ALL) who was treated with chemotherapy which included vincristine. Two weeks after the treatment startedparalytic ileus developed which was later sucessfully treated with laxatives and prokynetic drugs. Secondary causes for ileus development were excluded. Literature data was reviewed and a higher incidence of paralytic ileus in vincristine treated patients was found, especially when they are given concomitant itraconazole. Our patient received concommitant itraconazoleas a part of antifungal prophylaxis against invasive aspergillosiswhich is a perceived routine on hematological departments. Conclusions. Vincristine treated patients should be carefully observed regarding bowel peristaltics and obstipation. If obstipation or even paralyticileus developes, we must stop vincristine therapy. All patients receiving vincristine must receive fluconazol instead of itraconazol as a partof antifungal prophylaxis.

10.04.2014