341 research article The role of neoadjuvant chemotherapy in patients with advanced (stage IIIC) epithelial ovarian cancer Erik Skof1, Sebastjan Merlo2, Gasper Pilko2, Borut Kobal3 1 Department of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia 2 Department of Surgery, Institute of Oncology Ljubljana, Ljubljana, Slovenia 3 Division of Gynaecology and Obstetrics, University Medical Centre Ljubljana, Ljubljana, Slovenia Radiol Oncol 2016; 50(3): 341-346. Received 29 May 2015 Accepted 5 September 2015 Correspondence to: Borut Kobal, M.D., Division of Gynaecology and Obstetrics, University Medical Centre Ljubljana, Ljubljana, Zaloska 2, SI-1000 Ljubljana, Slovenia. E-mail: borut.kobal@kclj.si Disclosure: The authors declare no conflict of interest. Background. Primary treatment of patients with advanced epithelial ovarian cancer consists of chemotherapy either before (neoadjuvant chemotherapy, NACT) or after primary surgery (adjuvant chemotherapy). The goal of primary treatment is no residual disease after surgery (R0 resection) what is associated with an improvement in survival of patients. There is, however, no evidence of survival benefits in patients with R0 resections after prior NACT. Methods. We retrospectively reviewed the records of patients who were treated with diagnosis of epithelial ovarian cancer at Institute of Oncology Ljubljana in the years 2005-2007. The differences in the rates of R0 resections, progression free survival (PFS), overall survival (OS) and in five-year and eight-year survival rates between patients treated with NACT and patients who had primary surgery were compared. Results. Overall 160 patients had stage IIIC epithelial ovarian cancer. Eighty patients had NACT and eighty patients had primary surgery. Patients in NACT group had higher rates of R0 resection (42% vs. 20%; p = 0.011) than patients after primary surgery. PFS was 14.1 months in NACT group and 17.7 months after primary surgery (p = 0.213). OS was 24.8 months in NACT group and 31.6 months after primary surgery (p = 0.012). In patients with R0 resections five-year and eight-year survival rates were 20.6% and 17.6% in NACT group compared to 62.5% and 62.5% after primary surgery (p < 0.0001), respectively. Conclusions. Despite higher rates of R0 resections achieved by NACT, survival of patients treated with NACT was inferior to survival of patients who underwent primary surgery. NACT should only be offered to patients with advanced epithelial cancer who are not candidates for primary surgery. Key words: advanced ovarian cancer; neoadjuvant chemotherapy; primary surgery Introduction The standard treatment of patients with advanced epithelial ovarian cancer is a combination of primary surgery followed by chemotherapy. In the recent years it became clear that the goal of surgery is to achieve no macroscopic residual disease, since the survival of patients with no residual disease is superior to survival of patients with visible residual disease.1 To achieve this goal, several aggressive surgical techniques have been proposed. Often multivisceral resections are performed (diaphragm resection, splenectomy, colon resection, extensive peritonectomy, etc.)2, which increase morbidity of patients. Not all patients are candidates for primary surgery, either due to extend of their disease (unlikely to achieve no residual disease) or due to poor general condition (too ill to undergo an extensive operation). In this situation patients are treated with initial (neoadjuvant) chemotherapy, typically a combination of a platinum-based drug and a tax- Radiol Oncol 2016; 50(3): 269-273. doi:10.1515/raon-2016-0025 342 Skof E et al. / Advanced ovarian cancer and neoadjuvant chemotherapy ane.3 Patients, who are treated with neoadjuvant chemotherapy, are more likely to undergo surgery with no residual disease than patients with primary surgery.4 Therefore many authors believe that neoadjuvant chemotherapy is justified in order to have best chance to achieve a status of no residual disease.45 However, treatment with neoadjuvant chemotherapy has not yet been shown to provide better survival than treatment with primary surgery.46 It has been shown that survival of patients with stage III or IV who have no residual disease after primary surgery can be up to 50% at 10 years.7 It is not known, if patients who achieve a status of no residual disease with neoadjuvant chemotherapy, Primary surgery? 0-no, 1-yes Jlo _m Months FIGURE 1. Progression free survival of patients after primary surgery and neoadjuvant chemotherapy (NACT). Primary surgery? 0-no, 1-yes Jlo _rii + 0-censored + 1-censored T-1-T 0,00 20,00 40,00 i-1-]-r ,00 80,00 100,00 120,00 Months FIGURE 2. Overall survival of patients after primary surgery and neoadjuvant chemotherapy (NACT). have the same or equally good prognosis. There are data from one randomized trial which showed similar survival of patients treated with neoadju-vant chemotherapy to those treated with primary surgery, but, this study was criticized due to poor survival rates in both groups.4 We compared the differences in the rates of no residual disease (R0 resection) after surgery and the differences in five-year and eight-year survival rates in patients treated with neoadjuvant chemotherapy or primary surgery in correlation to the extent of residual disease post-surgery. Methods Patients We retrospectively reviewed the records of patients who were treated with diagnosis of epithelial ovarian cancer at Institute of Oncology Ljubljana in the period from 1st of January 2005 until 31st of December 2007. During this period we identified 346 patients who were treated for epithelial ovarian cancer. Of these 160 patients had stage FIGO IIIC disease - they were eligible for analysis. Of the 160 eligible patients, 80 patients had neoadjuvant chemotherapy (NACT) and 80 patients had primary surgery. Patients had primary surgery in seven different hospitals performed by many gynecologic surgeons. In all patients, hysterectomy, bilateral oophorectomy, infracolic omentectomy with limited peritonectomy was performed. In only few of the patients multivisceral resections (diaphragm resection, splenectomy, colon resection, extensive peritonectomy) were performed - therefore no comparison between different surgical techniques outcomes was carried out. In the NACT group 40% of patients received platinum and taxane therapy (paclitaxel 175mg in 3h i.v. infusion and carboplatin AUC 6 i.v. infusion) and 55% of patients received carboplatin (AUC 6) monotherapy before surgery. Post-surgery all patients received 3 additional cycles of chemotherapy - the same regimen as in neoadjuvant setting. Median number of cycles in NACT group was 7 (range 1-13). Of the 80 patients, who had primary surgery, 82% of them received platinum and taxane therapy (paclitaxel 175mg in 3h i.v. infusion and carboplatin AUC 6 i.v. infusion), 16% of patients received carboplatin (AUC 6) monotherapy. Median number of cycles of chemotherapy was 6 (range 1-9). All patients were treated with chemotherapy at Radiol Oncol 2016; 50(3): 341-346. 343 Skof E et al. / Advanced ovarian cancer and neoadjuvant chemotherapy Institute of Oncology Ljubljana by medical oncologist specialized for gynecologic oncology. Reasons given for NACT included extent of disease (50%), co-morbidities (10%), and poor performance (40%). For patients who had NACT, stage was established by combination of clinical examination, imaging (US, CT of abdomen), cytology and biopsy. For patients who were treated with primary surgery, stage was established by intraoperative examination and review pf pathology reports. The extent of residual disease was based on the diameter of the single largest lesion. Patients without macroscopic evident residual lesions had R0 resection, patients with less than 10 mm residual lesions had R1 resection, patients with residual lesions of 10 mm or more had R2 resection. Our retrospective study was approved by the Institutional Review Board and Ethics Committee. TABLE 1. The characteristics of patients and surgical outcomes Primary surgery N = 80 NACT N = 80 p Age (years) 60.2 64.8 0.006 High grade serous 43 (54%) 53 (66%) 0.307 Performance 0 or 1 >1 66 (83%) 14 (17%) 32 (40%) 48 (60%) < 0.0001 R0 resection 16 (20%) 34 (42%) 0.011 R1 resection 18 (23%) 18 (22%) 1.0 R2 resection 46 (57%) 11 (14%) < 0.0001 Inoperable - 17 (21%) - PFS (months) 17.7 14.1 0.213 OS (months) 31.6 24.8 0.012 NACT = neoadjuvant chemotherapy; OS = overall survival; PFS = progression-free survival; R0 = no macroscopic residual disease; R1= <1 cm residual disease; R2= >1 cm residual disease Analysis We compared patients who had NACT with those who had primary surgery for a range of clinical variables. The extent of residual disease post-surgery was measured. We observed the differences in the rates of no residual disease after surgery, differences in progression free survival (PFS), overall survival (OS) and in five-year and eight-year survival rates in patients after various treatments. Patients were followed from the date of diagnosis until death from ovarian cancer, death from another cause or lost from follow-up. The primary endpoints were OS, five-year and eight-year survival rates. The secondary end points were R0 resection rates and PFS. Survival curves were calculated by Kaplan-Meier's method. Univariate and multivariate analyses using log-rank test and Cox's regression model were used for the assessment of the factors associated with OS and for comparison of factors between patients who had NACT with those who had primary surgery. Quantitative variables were compared using Student or the Wilcoxon test. Categorical variables were compared using Chi-square test. The differences were considered statistically significant if the p values were less than 0.05. Software package SPSS 15.0 for Windows was used. Results We analyzed 160 patients with stage IIIC epithelial ovarian cancer who were treated at Institute of Oncology Ljubljana in the period from 1st of TABLE 2. Five-year and eight-year survival of patients after different surgical outcomes Five-year survival Eight year survival p Surgery -NACT - - R0 resection R0 resection 62.5% 20.6% 62.5% 17.1% P < 0.0001 Surgery -NACT - ■ R1 resection R1 resection 38.9% 16.7% 27.8% 11.1% P < 0.0001 Surgery -NACT - R2 resection R2 resection 15.5% 0% 0% 0% P < 0.0001 Inoperable disease 0% 0% - NACT = neoadjuvant chemotherapy; R0 = no macroscopic residual disease; R1= <1 cm residual disease; R2= >1 cm residual disease January 2005 until 31st of December 2007. Median follow-up of patients was 8.4 years (range 6.7-10 years). Of 160 patients, 80 patients had primary surgery and 80 patients had NACT. The characteristics of patients and surgical outcomes of patients who had primary surgery or NACT are shown in Table 1. Patients treated with primary surgery were younger (60.2 vs. 64.8 years; p < 0.001). Patients treated with primary surgery also had a better performance status according to WHO classification (p < 0.001). In patients treated with NACT higher rates of R0 resection were observed (42% vs. 20%; p < 0.001) and lower rates of R2 resection rates (14% vs. 57%; p < 0.001) compared to patients who had primary surgery. After NACT in 21% of patients disease remained to be inoperable. Median PFS of patients was 14.1 months after NACT and 17.7 months after primary surgery (Figure 1). The difference was not statistically sig- Radiol Oncol 2016; 50(3): 341-346. 344 Skof E et al. / Advanced ovarian cancer and neoadjuvant chemotherapy TABLE 3. Factors correlated with survival on univariate analysis Age (years) < 40 0.008 > 60 Histology High grade serous 0.066 Other histology Performance status 0 or 1 > 1 < 0.0001 Extent of residual disease R0 < 0.0001 Kl R2 Therapy Primary surgery 0.012 NACT NACT = neoadjuvant chemotherapy TABLE 4. Factors correlated with survival on multivariate analysis Age (years) < 40 0.775 > 60 Histology High grade serous 0.370 Other histology Performance status 0 or 1 > 1 0.003 Extent of residual disease R| < 0.0001 R2 Therapy Primary surgery 0.038 NACT NACT = neoadjuvant chemotherapy nificant (p = 0.213). Median OS of patients was 24.8 months after NACT and 31.6 months after primary surgery (Figure 2). The difference was statistically significant (p = 0.012). Five-year and eight-year survival rates of patients after different surgical outcomes are shown in Table 2. Patients treated with primary surgery had superior five-year and eight-year survival rates in all types of surgical outcomes compared to patients treated with NACT. Five-year and eight year survival rates were 62.5% and 62.5% vs. 20.6% and 17.1% after R0 resection (p < 0.001), 38 .9% and 27.8% vs. 16.7% and 11.1% after R1 resection (p < 0.001) and 15.5% and 0% vs. 0% and 0% after R2 resection (p < 0.0001), respectively. Survival curves of patients after different surgical outcomes are shown in Figure 3. Univariate analysis showed that factors associated with survival were: performance status according to WHO (p < 0.0001), extent of residual disease (p < 0.0001), primary surgery (p = 0.012) and age (p = 0.008) (Table 3). We conducted multivariate survival analysis using Cox's regression model. The following prognostic factors in the multivariable model: patient age at diagnosis (< 60 vs. > 60 years); extent of residual disease (R0, R1, R2); chemotherapy (NACT vs. primary surgery); performance status according to WHO (0 or 1 vs. > 1) and histopathological subtype (high grade serous vs. other) were entered. Patients treated with primary surgery had better survival also on multivariate survival analysis. Besides that, other independent predictors of survival were extent of residual disease and performance status (Table 4). Discussion Our results show that treatment with NACT doubles the chance to have no visible residual disease (R0 resection) post-surgery compared to primary surgery in patients with stage IIIC epithelial ovarian cancer (42% vs. 20%). This is in concordance with already published studies.4,5 Despite higher rates of R0 resections achieved by NACT, survival of patients treated with NACT was inferior to survival of patients who underwent primary surgery by almost 7 months (24.8 months vs. 31.6 months). Even in patients who had R0 resection post-surgery, there was a huge difference in probability to be five-year or eight-year survivor in favor of primary surgery. Patients with R0 resection at primary surgery had three-fold higher rates of five-year and eight-year survival rates than patients with R0 resection after NACT (62.5% vs. 20.6% and 62.5% vs. 17.1%, respectively). Our results are in concordance with many authors who reported similar results with inferior overall survival of patients after NACT despite higher rates of optimal debulking surgery.5-8 There have been published results of a randomized trial which showed similar survival of patients treated with NACT to those treated with primary surgery, but, this study was criticized due to poor survival rates in both groups.4 The limitation of our study was, that this was not a randomized trial, therefore at least to some extent the difference in the outcomes for the different groups might be the result of an imbalance in the baseline characteristics. Patients who received p p Radiol Oncol 2016; 50(3): 341-346. 345 Skof E et al. / Advanced ovarian cancer and neoadjuvant chemotherapy NACT were more likely to have more extensive disease at diagnosis than patients who had primary surgery, and therefore it was expected to do relatively worse. Patients who received NACT were almost five years older (64.8 years vs. 60.2 years), had more co-morbidities and had worse performance than patients who had primary surgery. Half of the patients who received NACT did not receive combination of taxane and carboplatin chemotherapy due to poor performance or co-morbidities, whereas vast majority of patients received combination of taxane and carboplatin after primary surgery. Multivariate analysis showed that independent predictors of survival were primary surgery, performance status and extent of residual disease. Therefore, a profound differences in survival among patients after R0 resection (and also R1 resection) between primary surgery and NACT can be at least to some extend explained by factors, other than disease itself. Authors believe that it is improper to compare survival of patients who had R0 resection at primary surgery to patients who had R0 resection after prior NACT if the patients are not balanced regarding performance status, age, comorbidities, etc. It is like comparing apples with oranges. It is not just the extent of the disease at diagnosis that is important for prognosis. The biology of the disease may also play an important role. At the moment there are no biologic markers that would help us to choose the best treatment strategy for patients with advanced epithelial ovarian cancer. It is known that the most common histologic type of epithelial ovarian cancer, high grade serous adenocarcinoma, is sensitive to chemotherapy, while other histologic types such as clear cell and mucinous ovarian cancer are resistant to chemotherapy. In the last years much effort has been done in discovering of predictive and prognostic molecular markers with molecular profiling of epithelial ovarian cancer. Recently published data have shown that at least three molecular subtypes of high-grade serous ovarian cancer exist, which may have different predictive and prognostic values in systemic treatment of patients with advanced epithelial ovarian cancer.9 At the moment there is still no consensus regarding the use of NACT. The lack of consensus on who are candidates for NACT was reflected at the fourth Gynecologic Cancer InterGroup (GCIG) consensus conference.10 While the majority of attendees felt that NACT was a standard option for all patients with advanced epithelial ovarian cancer, others felt that NACT should be offered to a more clearly defined subgroup of women in whom p<0.0001 0,0- _n R0 _n R1 _n R2 J! NACT R0 _n NACT R1 _n NACT R2 _f"l Inoperable -(- 0-censored -(- 1-censored -(- 2-censored -(- 3-censored 4-censored I 0,00 20,00 40,00 60,00 80,00 100,00 120,00 Months FIGURE 3. Survival curves of patients after different surgical outcomes. NACT = neoadjuvant chemotherapy; R0 = no macroscopic residual disease; R1= <1 cm residual disease; R2= >1 cm residual disease upfront surgery is contraindicated. The decision on whether to treat with NACT is based on the clinical status of the patient and whether or not disease is resectable at the time of presentation. Therefore, all patients require clinical staging. There are widely accepted criteria for unresectability.11 It is often difficult to preoperatively assess whether patients with advanced epithelial ovarian cancer can be optimally cytoreduced at the time of primary sur-gery.12 Therefore, many authors perform a staged surgical assessment for these patients and perform a diagnostic laparoscopy to further evaluate for resectability. If the surgeon conducting the assessment feels disease is resectable, primary surgery should be performed. If complete resectability is unlikely, NACT can be administered. Despite better overall survival of our patients who had primary surgery, two-thirds of patients in this group had R2 resection (> 1 cm residual disease) which is considered as a sub-optimal resection. These patients had five-year survival rates of only 15.5% with none being alive at eight years post-surgery. In NACT group there were only 14 % of patients with R2 resection. We believe that the main reason for high rate of R2 resections at primary surgery was that primary surgery was performed in different hospitals mainly by surgeons not skilled with principles of oncology surgery, whereas all patients who had NACT underwent surgery provided by surgeon experienced in oncology. There are convincing data showing that surgical expertise plays a major role in outcome of patients with advanced epithelial ovarian cancer. In 1,0— 0,8 r 0,6 — at 0,4 0,2 — Radiol Oncol 2016; 50(3): 341-346. 346 Skof E et al. / Advanced ovarian cancer and neoadjuvant chemotherapy multidisciplinary cancer centers with advanced expertise in gynecologic oncology, optimal debulking rates in excess of 70% have been reported even for patients with bulky stage IIIC disease.7 Therefore, it is strongly recommended that a gynecologic oncologist must be involved in surgical decision making and treatment in these circumstances. We believe there is enough evidence that in operable disease primary surgery with aim of no residual disease should be performed, since this offers best possible survival of patients with stage IIIC epithelial ovarian cancer.1 Of course patients must be fit enough for surgery, in which often multivisceral resections are needed with intention to achieve no residual disease post-surgery, which increase morbidity of patients.2 The NACT should only be offered to patients who are not candidates for primary surgery for whatever reason (advanced disease, poor performance, comorbidities, etc.). The aim of NACT should be to convert inoperable advanced disease to operable disease with goal to achieve optimal debulking (R0 resection). We believe that in patients with advanced epithelial ovarian cancer the aim of treatment should not only be the survival benefit but also the improvement in quality of life. Latter can be achieved by direct effect of chemotherapy on downsizing tumor burden, which offers higher chance for improvement in performance by lessening of the disease symptoms, offers higher chance to achieve optimal debulking at surgery, with less postoperative complications.4513 Since this was a retrospective study, a comparison of the quality of life between patients treated with NACT or primary surgery was not performed. One of the remarks towards NACT was that patients who started their treatment with NACT never had the chance for complete or optimal cy-toreductive surgery. Since 48% of patients who received NACT in our study population were not candidates for radical or ultraradical surgical procedures as a result of poor performance status or comorbidities, they should probably be excluded from comparison with patients who were capable to undergo primary surgery. Perhaps the survival of patients who had NACT, but were otherwise fit for primary surgery, should be compared to survival of patients who had suboptimal primary surgery (R2 resection), thus comparing different treatments for similar burden of the disease. If we compare these two groups of patients we can see that five-years survival rates in NACT group with R0 or R1 post-surgery (NACT-R0 and NACT-R1) were somewhat higher compared to patients who had R2 resection at primary surgery (20.6% after NACT-R0 surgery, 16.7% after NACT-R1 surgery and 15.5% after R2 primary surgery), the difference was not statistically significant. To conclude, our results show that treatment with NACT doubles the chance to have no visible residual disease (R0 resection) post-surgery compared to primary surgery in patients with advanced (stage IIIC) epithelial ovarian cancer. Despite higher rates of R0 resections achieved by NACT, survival of patients treated with NACT was inferior to survival of patients who underwent primary surgery by almost 7 months. Therefore we strongly believe that NACT should only be offered to patients with advanced epithelial cancer who are not candidates for primary cytoreductive surgery, or when the disease is unresectable after staged surgical assessment performed by oncology surgeon. References 1. Aletti GD, Dowdy SC, Gostout BS, Jones MB, Stanhope CR, Wilson TO, et al. Aggressive surgical effort and improved survival in advanced-stage ovarian cancer. Obstet Gynecol 2006; 107: 77-85. 2. Eisenkop SM, Spirtos NM. Procedures required to accomplish complete cytoreduction of ovarian cancer: is there a correlation with "biological aggressiveness" and survival? Gynecol Oncol 2001; 82: 435-41. 3. Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, Burger RA, et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 2003; 21: 3194-200. 4. Vergote I, Trope CG, Amant F, Kristensen GB, Ehlen T, Johnson N, et al. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med 2010; 363: 943-53. 5. Vergote I, Leunen K, Amant F. Primary surgery or neoadjuvant chemotherapy in ovarian cancer: what is the value of comparing apples with oranges? Gynecol Oncol 2012; 124: 1-2. 6. Bristow RE, Chi DS. Platinum-based neoadjuvant chemotherapy and interval surgical cytoreduction for advanced ovarian cancer: a meta-analysis. Gynecol Oncol 2006; 103: 1070-6. 7. Chi DS, Musa F, Dao F, Zivanovic O, Sonoda Y, Leitao MM, et al. An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debulking surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadjuvant chemotherapy (NACT). Gynecol Oncol 2012; 124: 10-4. 8. Rosen B, Laframboise S, Ferguson S, Dodge J, Bernardini M, Murphy J, et al. The impacts of neoadjuvant chemotherapy and of debulking surgery on survival from advanced ovarian cancer. Gynecol Oncol 2014; 134: 462-7. 9. GourleyC, McCavigan A, Perren T, Paul J, OgilvieMichie C, Churchman M, et al. Molecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumab. [Abstract]. J Clin Oncol 2014; 32(5 Suppl): abstract No. 5502. 10. Vergote I, du Bois A, Amant F, Heitz F, Leunen K, Harter P. Neoadjuvant chemotherapy in advanced ovarian cancer: On what do we agree and disagree? Gynecol Oncol 2013; 128: 6-11. 11. Stuart GC, Kitchener H, Bacon M, duBois A, Friedlander M, Ledermann J, et al. 2010 Gynecologic Cancer InterGroup (GCIG) consensus statement on clinical trials in ovarian cancer: report from the Fourth Ovarian Cancer Consensus Conference. Int J Gynecol Cancer 2011; 21: 750-5. 12. Salani R, Bristow RE. Surgical management of epithelial ovarian cancer. Clin Obstet Gynecol 2012; 55: 75-95. 13. Thrall MM, Gray HJ, Symons RG, Weiss NS, Flum DR, Goff BA. Neoadjuvant chemotherapy in the Medicare cohort with advanced ovarian cancer. Gynecol Oncol 2011; 123: 461-6. Radiol Oncol 2016; 50(3): 341-346. VIII Slovenian abstracts Radiol Oncol 2016; 50(3): 341-346. doi:10.1515/raon-2016-0034 Vloga neoadjuvantne kemoterapije pri bolnicah z napredovalim epitelijskim rakom jajčnika (stadij IIIC) Škof E, Merlo S, Pilko G, Kobal B Izhodišča. Primarno zdravljenje bolnic z napredovalim epitelijskim rakom jajčnika vključuje kemoterapijo pred (neoadju-vantna kemoterapija) ali po zamejitveni operaciji (adjuvantna kemoterapija). Cilj primarnega zdravljenja epitelijskega raka jajčnika je odstranitev vsega rakastega tkiva brez makroskopskega ostanka. Popolna resekcija (R0) po primarnem kirurškem zdravljenju predstavlja pomemben dejavnik v izboljšanju preživetja bolnic, medtem ko za enkrat še ni dokazov o enakem vplivu R0 resekcije, če primarno zdravljenje začnemo z neoadjuvantno kemoterapijo. Bolnice in metode. V letih od 2005 do 2007 smo na Onkološkem inštitutu pregledali popise bolnic z diagnosticiranim epitelijskim rakom jajčnika. Med bolnicami, ki so zdravljenje začele z neoadjuvantno kemoterapijo in tistimi, ki so bile primarno operirane, smo primerjali stopnjo dosežene kirurške resekcije, čas do ponovitve bolezni, ter petletno in osemletno preživetje. Rezultati. V raziskavo smo zajeli 160 bolnic s stadijem IIIC epitelijskega raka jajčnika. 80 bolnic smo pričeli zdraviti z neoadjuvantno kemoterapijo, pri preostalih 80-ih bolnicah pa je bilo primarno zdravljenje kirurško. Bolnice v skupini z neoadjuvantno kemoterapijo so imele višjo stopnjo resekcije R0 (42 % vs. 20 %; p = 0,011) kot bolnice s primarnim kirurškim zdravljenjem. Čas do ponovitve bolezni je bil v skupini z neoadjuvantno kemoterapijo 14,1 mesecev, po primarnem kirurškem zdravljenju pa 17,7 (p = 0,213). Celokupno preživetje je bilo 24,8 meseca v skupini z neoadjuvantno kemoterapijo in 31,6 meseca po primarni kirurgiji (p = 0,012). Pri bolnicah z doseženo resekcijo R0 sta bila petletno in osemletno preživetje v skupini z neoadjuvantno kemoterapijo 20,6 % in 17,6 % , v skupini s primarno kirurgijo pa 62,5 % in 62,5 % (p < 0,0001). Zaključki. Kljub večjemu deležu resekcije R0, ki smo jo dosegli v skupini, ki je začela zdravljenje z neoadjuvantno kemoterapijo, je bilo preživetje teh bolnic nižje od preživetja bolnic s primarnim kirurškim zdravljenjem. Neoadjuvantna kemoterapija tako ostaja prednostna za bolnice z napredovalim epitelijskim rakom jajčnika, ki niso primerne za primarno radikalno kirurško zdravljenje. Radiol Oncol 2016; 50(3): I-VIII.