Zdravljenje primarne plazmacelične levkemije
Treatment of primary plasma cell leukemia

slovenian

2003

volume 72, issue 4

Slovensko zdravniško društvo
(Obvezni izvod spletne publikacije)

Background. The author describes long-term survival in 3 patients with primaryplasma cell leukaemia (PL) after different therapeutic regimen and maintenance treatment with interferon alpha (INF). Patients and treatment. In a 52 year-old male patient, a partial remission of PL was achieved after 6 months of treatment with melphalan and prednisone. The patient did not consentto stem cell transplantation (SCT). An 86 year-old female patient with PL achieved a complete remission after 6 months of treatment with vincristine,doxorubicin and dexamethasone. A 31 year-old male patient experienced a complete remission of PL after 6 months of treatment with cyclophosphamide, vincristine, doxorubicin, methilprednisone, followed by autologous SCT. All three patients were placed on maintenance therapy with INF-2b(IntronA)3 X 106IU given subcutaneously on two days per week. In the 52 year-old man, the remission lasted 9 months and in the woman 23 months, where upon they developed a relapse with signs of disseminated plasmacytoma. In bothpatients the former chemotherapy was applied again, resulting in a slight improvement. The man died 37 months and the woman 43 months after the diagnosis of PL, while the youngest patient has been in complete remission for82 months. Conclusions. Long remission achieved in ourpatients confirmed the favourable effect of INF in terms of prolongation of the remission duration in this patients. The effect of maintenance treatment with INF is usually directly dependent on the degree of remission induced by different therapeutic regimen.

15.05.2023