Telesna vadba pri bolnikih s kroničnim srčnim popuščanjem
Physical training in patients with chronic heart failure

slovenian

2000

volume 39, issue 4

Heart failure, congestive    Exercise test    Exercise therapy    Brachial artery    Ultrasonography 

Društvo Medicinski razgledi
(Obvezni izvod spletne publikacije)

Exercise intolerance, a key symptom of chronic heart failure; has been linked to peripheral derangements, and marked endothelial dysfunction (i. e. the inability of endothelium to mediate a proper vasodilatatory response to physiologic stimuli) has been postulated to be one of the main causes. We hypothesized that supervised aerobic leg training improves endothelial function in the upper limb vessels. In our prospective study, 24 patients (3 women, 21 men, aged 50-80 years) with chronic heart failure were randomized toa control or a training group; which attended one-hour training sessions 3 times a week for 8 weeks. Before and after the training period, clinical and biochemical parameters, exercise capacity as well as endothelial dysfunction were determined. Endothelial dysfunction was assessed by high-resolution ultrasound measurements of brachial artery diameter and peak flow velocity at rest, after reactive hyperemia (causing flow mediated endothelium-dependent dilation), and after gylceriltrinitrate administration (causing endothelium-independent vasodilatation). (Abstract truncated at 2000 characters)

02.07.2015