Pomen cisteinskih peptidaz pri nevrodegenerativnih boleznih
Importance of cysteine peptidases in neurodegenerative disorders

slovenian

2022

volume 73, issue 5

Slovensko farmacevtsko društvo
(Obvezni izvod spletne publikacije)

The nervous system represents a broad field of potential pharmacological targets suitable for the development of new compounds for the treatment of neurological and neurodegenerative diseases. To date, a lot of research has focused on the role of cysteine peptidases, which play an important role in degradation of brain peptides playing either a neuroprotective or neurodegenerative role. Activated microglia has a significant role in inflammation-related neurodegeneration. By releasing cysteine cathepsins it promotes the development of Alzheimer's and Parkinson's disease. The proteolytic activity of cysteine cathepsins can be regulated by endogenous or exogenous inhibitors. Exogenous inhibitors open up possibilities for the development of new therapeutic approaches for the treatment of neurodegenerative diseases.

29.08.2023