Regressing anaplastic CD30-positive large-cell lymphoma of the skin

english

2006

volume 15, issue 3

Aged   Diagnosis   Lymphoma, Large-Cell, Ki-1   Pathology   Skin Neoplasms   tumor

Združenje slovenskih dermatovenerologov
(Obvezni izvod spletne publikacije)

Originally believed to be of histiocytic origin, regressing primary cutaneous anaplastic large-cell lymphoma is a CD30 (Ki 1) positive T-cell lymphoma with histologic high grade malignancy, but with an often favorable clinical course with regression of individual lesions. We present a case of a 69-year-old white woman with an 8-month history of noduloulcerative lesions on her right lower leg, otherwise in good general health. The clinical, histologic, and immunohistochemical findings pointed to CD30 positive primary cutaneous anaplastic large-cell lymphoma. There were no signs of generalization, lymph node or internal organ involvement. After 2 years of activity, the disease regressed. During the 10-year follow-up period, no signs of disease reactivation were noted. Accurate recognition of this lymphoma is important toavoid unnecessary aggressive treatments.

11.04.2014